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Polycystic Kidney Disease (PKD)

What is Polycystic Kidney Disease (PKD)?

Polycystic kidney disease (PKD) is a condition in which clusters of cysts grow in the body, mainly in the kidney. Cysts are round sacs with fluid in them. They are not cancer and can vary in size, sometimes growing very large. Have many cysts or having large cysts can damage the kidney and over time, the cysts may cause the kidney to stop working by constricting healthy kidney tissues and affecting kidney function. 

If left untreated, PKD may cause serious complications, including high blood pressure and kidney failure, as PKD can cause cysts to grow in the liver, the pancreas and other places in the body. PKD also causes chronic kidney disease, which can progress to kidney failure. 

Types of Polycystic Kidney Disease (PKD)

  • Autosomal dominant polycystic kidney disease (ADPKD): The most common form of PKD. Most people are diagnosed with ADPKD in adulthood between the ages of 30 to 50. But it can still occur in childhood. 
  • Autosomal recessive polycystic kidney disease (ARPKD): ARPKD is a rarer form of PKD is caused by abnormal kidney development during fetal development. 


What are the symptoms of Polycystic Kidney Disease (PKD)?

Symptoms can vary depending on the type of PKD you have.

Signs of Autosomal Dominant Polycystic Kidney Disease (ADPKD):

  • Pain in your back or sides
  • High blood pressure
  • Headaches
  • Blood in your urine
  • Urinary tract infections
  • Kidney stones

Signs of Autosomal Recessive Polycystic Kidney Disease (ARPKD):

  • Low weight at birth
  • Swollen abdomen
  • High blood pressure
  • Breathing problems


What are the risk factors for Polycystic Kidney Disease (PKD)?

Polycystic kidney disease is a genetic condition and so you're at an increased risk of developing the disease if your parents also suffer from the condition. New mutations rarely occur in an individual without a family history of PKD leading to disease in them. 


What are the complications of Polycystic Kidney Disease (PKD)?

If left untreated, PKD can cause serious health complications for adults and babies. These complications include:

  • Kidney stones
  • High blood pressure
  • Urinary tract infections (UTIs)
  • Kidney failure
  • Liver and pancreatic cysts
  • Heart valve problems
  • High blood pressure during pregnancy

ARPKD may be fatal in babies who are born with a severe case of the disease.


How do you prevent Polycystic Kidney Disease (PKD)?

PKD is not preventable however after getting a diagnosis, you may be able to slow the disease's progression and kidney failure by practising a healthy lifestyle. It is important to work with your doctor to understand your risk of kidney failure and learn what you can do to manage it. 

Some steps to follow include:

  • Preventing or managing diabetes or high blood pressure
  • Maintaining a healthy weight
  • Staying hydrated
  • Take all of your prescribed medicine
  • Follow a kidney-health diet. Limit excess sodium, sugar and fat in your foods and eat more fruit and vegetables. 
  • Quit smoking


How do you diagnose Polycystic Kidney Disease (PKD)?

Imaging Test
Your healthcare provider may conduct an ultrasound, CT scan or MRI to check your kidneys.